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UFC 251: Usman vs. Masvidal was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on July 12, 2020 at the du Forum on Yas Island, Abu Dhabi, United Arab Emirates. A UFC Welterweight Championship bout between current champion Kamaru Usman and Gilbert Burns was expected to headline the event. However, it was announced on July 3 that Burns was pulled from the contest after he and his coach, Greg Jones, tested positive for COVID-19. Pending pre-fight testing and a 24-hour quarantine, Jorge Masvidal was expected to serve as his replacement. After he passed his initial test, the new main event was confirmed.

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